OVERDOSE PREVENTION FOR INJECTION DRUG USERS: LESSONS LEARNED FROM NALOXONE TRAINING AND DISTRIBUTION PROGRAMS IN NEW YORK CITY

Overdose prevention for injection drug users: Lessons learned from naloxone training and distribution programs in New York City

LEDs Abstract Background Fatal heroin overdose is a significant cause of mortality for injection drug users (IDUs).Many of these deaths are preventable because opiate overdoses can be quickly and safely reversed through the injection of Naloxone [brand name Narcan], a prescription drug used to revive persons who have overdosed on heroin or other op

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Beyond Gap Junction Channel Function: the Expression of Cx43 Contributes to Aldosterone-Induced Mesangial Cell Proliferation via the ERK1/2 and PKC Pathways

Aims: This study aimed to explore the precise mechanism and signaling pathways of mesangial cell (MC) proliferation from a new point of view considering Connexin 43 (Cx43).Methods: MC proliferation was measured by the incorporation of 3H-thymidine (3H-TdR).Cx43 was over-expressed in MC cells using lipofectamine 2000, and the expression level was te

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HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.

Host cells impose a broad range of obstacles to the replication of retroviruses.Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells.HIV-1 Vpu efficiently counteracts this restriction.Here, we show that HIV-1 Vpu induces the depletion of tetherin from cells.We demonstr

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